Dr. Marco A. Lopez


Dr. Marco A. Lopez


Professor (1987) 
Organic & Fe(II) Porphyrin Chemistry 

Teaching: Organic & general chemistry 
E-mail: marco.lopez@csulb.edu
Phone: 562.985.4936 
Office: HSCI-342

Teaching Interests


Research Interests: Ligand binding to Iron Porphyrins

There are three groups of projects in my lab: 1) binding studies of ligands to ferrous hemes, 2) synthesis of novel ferrous hemes, and 3) computational chemistry of ferrous hemes; these are described below. 1. Binding Studies of Ligands to Ferrous Hemes. We use UV-vis spectophotometry to mesure rate constants and equilibrium binding constants of ligands (e.g. CO, imidazoles, dimethylsulfoxide, water, methonal) to a variety of tetraphenyl iron porphyrins to characterize the ligand-heme interaction. 2. Synthesis of Novel Ferrous Hemes.We are interested in creating novel ferrous hemes so as to study electronic effects on the binding of ligands to the hemes.3. Computational Chemistry of Ferrous Hemes.We use a variety of computational methods to study the structure and vibrations of ferrous hemes. Computational packages used include AMBER, HyperChem, and SPARTAN. 


Selected publications

Lopez, M.A.; Kollman, P.A., "Application of Molecular Dynamics and Free Energy Perturbation Methods to Metalloporphyrin-Ligand Systems I: CO and Dioxygen Binding to Four Heme Systems" , J. Am. Chem. Soc., 1989, 111, 6212-6222.

Odasso, J.; Lopez, M.A.: "Development of Spectrophotometeric Methods for Studying Heme-Oxygen Complexes", Proceedings of the Fifth National Conference on Undergraduate Research, (1992), 191-196.

Lopez, M.A.; Kollman, P.A., "Application of Molecular Dynamics and Free Energy Perturbation Methods to Metalloporphyrin-Ligand Systems II: CO and Dioxygen Binding to Myoglobin," Protein Science, 1993, 2, 1975-1986.

David, S.; James, B.R.; Dolphin, D.; Traylor, T.G.; Lopez, M.A: "Dioxygen and Carbon Monoxide Binding to Apolar Cyclophane Hemes: Durene-Capped Hemes," J. Am. Chem. Soc., 1994, 116, 6-14.

Lopez, M.A., Ybarra, C.D., Hyatt, S. "The Chelation of Monochelated Protoheme," Inorganica Chimica Acta, 1995, 231, 121-131